Molecular weight (MW) markers are standards which determine the size of a molecule during electrophoresis. It is also referred as RNA, DNA, and protein ladder. These markers are run in polyacrylamide or agarose gels. Development of technologies such as next-generation sequencing (NGS) and polymerase chain reaction (PCR) encouraged the use of these markers in molecular biology. Interest in molecular biology research by major corporations is driving the global molecular-weight size marker market.
PCR-based markers were essential in detecting virus strains in human DNA. The DNA fragments can be cloned multiple times and used for probes and assays. AFLP (amplified fragment length polymorphism), RAPD (Random amplified polymorphic DNA), and microsatellites are different types of these markers. NGS has gained prominence in creating DNA markers on crops. This can be used to tag disease-resistant genes for molecular breeding.
Microarrays and RT-PCR (reverse transcription polymerase chain reaction) are methods which are used in studying gene expressions in animals. For instance, the one-step RT-PCR kit by Qiagen was used by doctors to detect strains of Crimean-Congo hemorrhagic fever (CCHF) in humans in Bulgaria. It has been used to reduce the rising incidence of deaths due to the disease by providing the right vaccine. Thermo Fisher Scientific offers a variety of DNA ladders available for a range of 10 bp (base pairs) to 12 kb (kilo base pairs) to identify molecular sizes.
The global molecular-weight size marker market is anticipated to exceed over USD 1 billion by 2025. It stood at USD 355.2 million in 2016. It is expected to expand at a 14.1% CAGR over the forecast period (2014 - 2025). It is driven by the surging demand of personalized medicine to treat chronic diseases.
DNA markers generated huge revenues for the market in 2016 and expects to grow at a significant rate during the forecast period. Proteomics application can grow robustly over the same period driven by clinical diagnostics and drug discovery. Asia Pacific market can expand at a significant growth rate over the forecast period due to rising focus of contract research organizations in DNA ladders. Prominent players comprise Promega Corporation; New England Biolabs; Thermo Fisher Scientific, Inc.; and Qiagen.
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